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Photo of Hannah Braß

Dr. Hannah Braß
Scientific assistant
02461-613745

Building: 15.8
Floor/Room: 212
Responsibilities

 

“The colourful world of prodiginines – New enzymes for the synthesis of bioactive natural product derivatives ”

 

ORCID


Curriculum Vitae

Academic Stages

since 2020 Postdoctoral studies

since 2016

 

Doctoral studies

2015

Master thesis at the group of Prof. Dr.-Ing. Lars Blank
Institute of Applied Microbiology (RWTH Aachen University)
» Investigation of rhamnolipid synthesis pathways in recombinant Pseudomonas putida «

2013-2015

Master studies in Molecular and Applied Biotechnology at
RWTH Aachen University

2013

Bachelor thesis at the group of Prof. Dr. Anett Schallmey
Institute of Biotechnology, Juniorprofessorship for Biocatalysis (RWTH Aachen University)

» Expression and characterization of the β-Etherase LigE1 from Novosphingobium sp. PP1Y for lignin degradation «

2010-2013

Bachelor studies in Molecular and Applied Biotechnology at
RWTH Aachen University

2010

Abitur

 

Awards & Scholarships

2016

Springorum Denkmünze, verliehen vom Förderverein der RWTH (proRWTH)

 

Publications

 

Publications

L. Berning, D. Schlütermann, A. Friedrich, N. Berleth, Y. Sun, W. Wu, M. J. Mendiburo, J. Deitersen, H. U. C. Brass, M. A. Skowron, M. J. Hoffmann, G. Niegisch, J. Pietruszka, B. Stork, Molecules 2021, 26, 1294, 'Prodigiosin Sensitizes Sensitive and Resistant Urothelial Carcinoma Cells to Cisplatin Treatment'.

S. Brands, J. G. Sikkens, M. D. Davari, H. U. C. Brass, A. S. Klein, J. Pietruszka, A. J. Ruff, U. Schwaneberg, Chem. Commun. 2021, 57, 2681–2684 'Understanding substrate binding and the role ofgatekeeping residues in PigC access tunnels'.

S. Brands, H. U. C. Brass, A. S. Klein, J. G. Sikkens, M. D. Davari, J. Pietruszka, A. J. Ruff, U. Schwaneberg, Catal. Sci. Technol. 2021, doi.org/10.1039/D0CY02297G, 'KnowVolution of prodigiosin ligase PigC towards condensation of short-chain prodiginines'.

S. S. Habash, H. U. C. Brass, A. S. Klein, D. P. Klebl, T. M. Weber, T. Classen, J. Pietruszka, F. M. W. Grundler, A. S. S. Schleker, Front. Plant Sci. 2020, 11, 579807; 'Novel Prodiginine Derivatives Demonstrate Bioactivities on Plants, Nematodes, and Fungi'.

S. Brands, H. U. Brass, A. S. Klein, J. Pietruszka, A. J. Ruff, U. Schwaneberg, Chem. Commun. 2020, 56, 8631–8634; 'A colourimetric high-throughput screening system for directed evolution of prodigiosin ligase PigC'.

H. U. C. Brass, A. S. Klein, S. Nyholt, T. Classen, J. Pietruszka, Adv. Synth. Catal. 2019, 361, 2659–2667; 'Condensing Enzymes from Pseudoalteromonadaceae for Prodiginine Synthesis'.

A. S. Klein, H. U. C. Brass, D. P. Klebl, T. Classen, A. Loeschcke, T. Drepper, S. Sievers, K.-E. Jaeger, J. Pietruszka, ChemBioChem 2018, 19, 1545–1552; 'Preparation of cyclic prodiginines by mutasynthesis in Pseudomonas putida KT2440'.

A. S. Klein, A. Domröse, P. Bongen, H. U. C. Brass, T. Classen, A. Loeschcke, T. Drepper, L. Laraia, S. Sievers, K.-E. Jaeger, J. Pietruszka, ACS Synth. Biol. 2017, 6, 1757–1765; 'New Prodigiosin Derivatives Obtained by Mutasynthesis in Pseudomonas putida'.

Lectures

 

Posters & Presentations

7th BioSC Spotlight „Modular biotransformations in a circular bioeconomy“, 05.02.2020, Aachen, Germany; A. Loeschcke, H. U. C. Brass, „Pseudomonas putida‐based production of diverse fine chemicals“. (Presentation)

BioTrans 2019, 07.–11.07.2019, Groningen, The Netherlands; H. U. C. Brass, A. S. Klein, S. Nyholt, T. Classen, J. Pietruszka; „Ligases in natural product synthesis – A bridge between chemistry and biology“. (Presentation, Poster)

Bayer, Science Lunch der Process Technology Development Gruppe (Division Engineering & Technology), 10.10.2018, Leverkusen, Germany; A. S. Klein, H. U. C. Brass; „Mutasynthese zur Produktion von Prodigininen als Wirkstoffe – Eine farbenfrohe Brücke zwischen Chemie und Biologie“. (Presentation upon inivitation)

EMBO Workshop „Enzymes, Biocatalysis and Chemical Biology – The new frontiers“, 09.–12.09.2018, Pavia, Italy; H. U. C. Brass, A. S. Klein, D. P. Klebl, T. Classen, A. Loeschcke, T. Drepper, S. Sievers, K.‐E. Jaeger, J. Pietruszka; „New bioactive prodigiosin derivatives – Biotechnology meets chemistry“. (Poster)

9th International Congress on Biocatalysis, 26.–30.08.2018, Hamburg, Germany; H. U. C. Brass, A. S. Klein, T. Classen, A. Loeschcke, T. Drepper, S. Sievers, K.-E. Jaeger, J. Pietruszka; „New bioactive prodigiosin derivatives – A bridge between chemistry and biology“. (Poster, Short Talk)

69. Mosbacher Kolloquium, 22.–24.03.2018, Mosbach, Germany; H. U. C. Brass, A. S. Klein, T. Classen, A. Loeschcke, T. Drepper, L. Laraia, S. Sievers, K.‐E. Jaeger, J. Pietruszka; „Creating Diversity in Prodiginines – Synthetic Biology meets Chemistry“. (Poster)

Directing Biosynthesis V, 22.–24.03.2017, Warwick, United Kingdom; H. U. C. Brass, A. S. Klein, T. Classen, A. Domröse, A. Loeschcke, T. Drepper, K.‐E. Jaeger, J. Pietruszka; „New Prodigiosin Derivatives – A mutasynthesis approach“. (Poster, Short Talk)

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