In his latest publication in Organic Letters, Moritz Klischan et al. used a cyclic diaryliodonium salt to synthesize 8,8''-biflavones for the first time.

By enantioselective ring opening of the diaryliodonium salt 2, both enantiomers of the 2,2-iodobiaryl 3 were obtained, from which the 1,3,5-substituted biaryl 4 was first synthesized. Based on this, both enantiomers of the bisphenol 5 with high ee were synthesized, from which a library of 8,8''-biflavones 6 with activity against HeLa cells was synthesized.

Congratulations on this work!