Personen
Dr. Hannah Braß
Wissenschaftliche Mitarbeiterin
02461-613745
Gebäude: 15.8
Etage/Raum: 212
Aufgabenfelder
“The colourful world of prodiginines – New enzymes for the synthesis of bioactive natural product derivatives ”
Curriculum Vitae
Academic Stages | |
| since 2020 | Postdoctoral studies |
since 2016
| Doctoral studies |
2015 | Master thesis at the group of Prof. Dr.-Ing. Lars Blank |
2013-2015 | Master studies in Molecular and Applied Biotechnology at |
2013 | Bachelor thesis at the group of Prof. Dr. Anett Schallmey » Expression and characterization of the β-Etherase LigE1 from Novosphingobium sp. PP1Y for lignin degradation « |
2010-2013 | Bachelor studies in Molecular and Applied Biotechnology at |
2010 | Abitur |
Awards & Scholarships | |
2016 | Springorum Denkmünze, verliehen vom Förderverein der RWTH (proRWTH) |
Publikationsverzeichnis
Publications |
L. Berning, D. Schlütermann, A. Friedrich, N. Berleth, Y. Sun, W. Wu, M. J. Mendiburo, J. Deitersen, H. U. C. Brass, M. A. Skowron, M. J. Hoffmann, G. Niegisch, J. Pietruszka, B. Stork, Molecules 2021, 26, 1294, 'Prodigiosin Sensitizes Sensitive and Resistant Urothelial Carcinoma Cells to Cisplatin Treatment'. |
S. Brands, J. G. Sikkens, M. D. Davari, H. U. C. Brass, A. S. Klein, J. Pietruszka, A. J. Ruff, U. Schwaneberg, Chem. Commun. 2021, 57, 2681–2684 'Understanding substrate binding and the role ofgatekeeping residues in PigC access tunnels'. |
S. Brands, H. U. C. Brass, A. S. Klein, J. G. Sikkens, M. D. Davari, J. Pietruszka, A. J. Ruff, U. Schwaneberg, Catal. Sci. Technol. 2021, doi.org/10.1039/D0CY02297G, 'KnowVolution of prodigiosin ligase PigC towards condensation of short-chain prodiginines'. |
S. S. Habash, H. U. C. Brass, A. S. Klein, D. P. Klebl, T. M. Weber, T. Classen, J. Pietruszka, F. M. W. Grundler, A. S. S. Schleker, Front. Plant Sci. 2020, 11, 579807; 'Novel Prodiginine Derivatives Demonstrate Bioactivities on Plants, Nematodes, and Fungi'. |
S. Brands, H. U. Brass, A. S. Klein, J. Pietruszka, A. J. Ruff, U. Schwaneberg, Chem. Commun. 2020, 56, 8631–8634; 'A colourimetric high-throughput screening system for directed evolution of prodigiosin ligase PigC'. |
H. U. C. Brass, A. S. Klein, S. Nyholt, T. Classen, J. Pietruszka, Adv. Synth. Catal. 2019, 361, 2659–2667; 'Condensing Enzymes from Pseudoalteromonadaceae for Prodiginine Synthesis'. |
A. S. Klein, H. U. C. Brass, D. P. Klebl, T. Classen, A. Loeschcke, T. Drepper, S. Sievers, K.-E. Jaeger, J. Pietruszka, ChemBioChem 2018, 19, 1545–1552; 'Preparation of cyclic prodiginines by mutasynthesis in Pseudomonas putida KT2440'. |
A. S. Klein, A. Domröse, P. Bongen, H. U. C. Brass, T. Classen, A. Loeschcke, T. Drepper, L. Laraia, S. Sievers, K.-E. Jaeger, J. Pietruszka, ACS Synth. Biol. 2017, 6, 1757–1765; 'New Prodigiosin Derivatives Obtained by Mutasynthesis in Pseudomonas putida'. |
Posters & Presentations |
7th BioSC Spotlight „Modular biotransformations in a circular bioeconomy“, 05.02.2020, Aachen, Germany; A. Loeschcke, H. U. C. Brass, „Pseudomonas putida‐based production of diverse fine chemicals“. (Presentation) |
BioTrans 2019, 07.–11.07.2019, Groningen, The Netherlands; H. U. C. Brass, A. S. Klein, S. Nyholt, T. Classen, J. Pietruszka; „Ligases in natural product synthesis – A bridge between chemistry and biology“. (Presentation, Poster) |
Bayer, Science Lunch der Process Technology Development Gruppe (Division Engineering & Technology), 10.10.2018, Leverkusen, Germany; A. S. Klein, H. U. C. Brass; „Mutasynthese zur Produktion von Prodigininen als Wirkstoffe – Eine farbenfrohe Brücke zwischen Chemie und Biologie“. (Presentation upon inivitation) |
EMBO Workshop „Enzymes, Biocatalysis and Chemical Biology – The new frontiers“, 09.–12.09.2018, Pavia, Italy; H. U. C. Brass, A. S. Klein, D. P. Klebl, T. Classen, A. Loeschcke, T. Drepper, S. Sievers, K.‐E. Jaeger, J. Pietruszka; „New bioactive prodigiosin derivatives – Biotechnology meets chemistry“. (Poster) |
9th International Congress on Biocatalysis, 26.–30.08.2018, Hamburg, Germany; H. U. C. Brass, A. S. Klein, T. Classen, A. Loeschcke, T. Drepper, S. Sievers, K.-E. Jaeger, J. Pietruszka; „New bioactive prodigiosin derivatives – A bridge between chemistry and biology“. (Poster, Short Talk) |
69. Mosbacher Kolloquium, 22.–24.03.2018, Mosbach, Germany; H. U. C. Brass, A. S. Klein, T. Classen, A. Loeschcke, T. Drepper, L. Laraia, S. Sievers, K.‐E. Jaeger, J. Pietruszka; „Creating Diversity in Prodiginines – Synthetic Biology meets Chemistry“. (Poster) |
Directing Biosynthesis V, 22.–24.03.2017, Warwick, United Kingdom; H. U. C. Brass, A. S. Klein, T. Classen, A. Domröse, A. Loeschcke, T. Drepper, K.‐E. Jaeger, J. Pietruszka; „New Prodigiosin Derivatives – A mutasynthesis approach“. (Poster, Short Talk) |